The short-term prognosis is very good. Once treated, one would expect symptoms of Cushing’s to fully resolve over the course of 4 – 6 months. Excess drinking and urinating will reduce rather quickly. It may take several months for hair and coat to improve. Dogs are generally more comfortable after the disease is under control and may live happily for years.
Left untreated, Cushing’s Disease will progress. As excess cortisol can suppress the function of the immune system, patients affected are prone to various infections. They are also predisposed to develop hypothyroidism, pancreatitis, diabetes, seizures, hypertension, congestive heart failure, blood clots, and liver and kidney failure.